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PremiumVIVAnews -Alan Aderem, Director of BioMed and Rino Rappuoli, Seattle, Global Head of Vaccines Research for Novartis Vaccines and Diagonstics, viewing the latest progress in the development of a vaccine in a scientific journal, Nature.
They write, it is estimated, by 2020, a vaccine for malaria, tuberculosis (TB) and HIV/AIDS have been found. In the journal that they also discussed the new devices including biological systems and the design of antigen-based structure that can provide a better understanding of the mechanisms of protection.
This device will give instructions to the rational development of vaccines to burden the people with infectious diseases are the most terrible in the world.
According to Aderem, a pioneer in the field of systems biology, new concepts and advances in technology have indicated that the vaccine to three infectious diseases reveals that will be developed in the next 10 years.
"Success will rely heavily on the ability of the US approach on biological systems to analyze the data generated during the test of proof," said Aderem, like diktutip of MedIndia, may 28, 2011.
Aderem mentions, the success of it will also give a new view, such as the identification of the relationship between protection or signs of immunogenicity and acceleration of large-scale clinical trials. In addition, add Aderem, a regulatory approach to a new and innovative clinic will also accelerate the discovery of vaccines-vaccines are badly needed.
In its report, Aderem and Rappuoli also reviews the advantages and disadvantages of system biology approach, with the main advantage of that approach is in its ability to capture and integrate data of very large amounts of biology to visualize the properties that appear are not indicated by the parts individually and could not be predicted if only use each section singly.
"The advantages of biological system is its ability to predict the behavior of the whole system of biology," said Aderem. "From there, we can optimize the vaccine candidate and to predict whether a drug or vaccine candidate could work before the medication was taken to large scale clinical trials that are very expensive," he said.
Biological systems can also be used to accelerate clinical trials usually last long.
Aderem and Rappuoli estimates that in the trials of a vaccine for malaria, TB and HIV/AIDS, only one hypothesis was tested every eight years in the last three decades. "We cannot continue to use this approach if we want to get in as soon as possible," said Aderem.
With this new method, said Aderem, we can accelerate the development of the clinic by doing a test run is more efficacious and by improving biological system design using approaches to test several hypotheses in parallel and have a design that is adaptive to expand results which proved most promising.
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